Wyeth's work was also gaining acclaim at that time through an exhibition of his pictures along with his father's and grandfather's in 1971 at the newly opened Brandywine River Museum in Chadds Ford. In the winter of 1975-1976, the Joslyn Art Museum in Omaha, Nebraska held the first full retrospective of his work, exhibiting more than 40 drawings, watercolors, and oils. An exhibition in 1976 at Coe Kerr Gallery, New York drew further national attention to Jamie's work when the Gallery showed the portraits he and the late Pop artist Andy Warhol did of one another. Since then, Wyeth has had several one-man exhibitions, including those at the Pennsylvania Academy of the Fine Arts, Philadelphia (1980), Amon Carter Museum, Fort Worth, Texas (1981), Anchorage Fine Arts Museum, Alaska (1983), Portland Museum of Art, Maine (1984) and Decatur House, Washington, D.C. (1995). His works are also included in many public collections, including The National Gallery of Art and The National Portrait Gallery, both in Washington, D.C.; John F. Kennedy Library and Museum in Boston, Massachusetts; The Museum of Modern Art, New York and the Brandywine River Museum in Chadds Ford, Pennsylvania, to name a few.

He lives with his wife, Phyllis, in Monhegan, Maine and Chadds Ford, Pennsylvania. He is represented by the Warren Adelson Gallery.