Bio Review Notes #53
PEPTIDE HORMONES
Performance Objectives:
Many hormones are short peptide sequences or small proteins.
Pituitary hormones control many other endocrine organs.
Hormones of the adrenal medulla stimulate a "fight or flight" response.
Thyroid and parathyroid hormones regulate metabolic rate and calcium.
The pancreas produces hormones that regulate glucose metabolism.
Other digestive organs produce hormones that regulate digestive functions.

Anterior pituitary gland: Derived from tissue that detaches from the roof of the mouth and lodges at the base of the brain. Many of the hormones produced here are called trophic hormones because they stimulate other glands to release their hormones.
  • Follicle-Stimulating Hormone (FSH): Stimulates growth and maturation of the gonads in both sexes, including secretion of their hormones.
  • Luteinizing hormone (LH): Stimulates ovulation in females.
  • Luteotrophic hormone (LTH): Stimulates secretion of progesterone.
  • Adrenal CorticoTrophic Hormone (ACTH): Stimulates adrenal cortex to produce its hormones.
  • ThyroTrophic Hormone (TTH): Stimulates the thyroid gland to produce thyroxin.
  • Growth Hormone (GH, somatostatin): Stimulates growth.
  • Melanocyte-Stimulating Hormone (MSH): Stimulates pigment cells.
Posterior pituitary hormones:
  • Vasopressin (Anti-Diuretic Hormone, ADH): Stimulates urinary retention of water and concentration of urine; lack of hormone causes excessive levels of urination, thirst, and drinking.
  • Oxytocin: Stimulates uterine contractions in childbirth, also milk production.
Pineal gland: Secretes melatonin during darkness, which regulates circadian rhythms and clues the body to day length and seasonal changes.

Adrenal medullary hormones: The medulla of the adrenal gland secretes epinephrine ("adrenalin") and norepinephrine. These hormones are also neurotransmitters. They stimulate a more rapid heartbeat and breathing, more blood flow to muscles (and less to the digestive tract), lowering of nerve thresholds (so nerves fire more easily), and shortening of blood clotting time. Overall, they prepare the body to "fight or flee."

Thyroid and parathyroid hormones:
  • Thyroxin (produced by thyroid gland): An iodine-containing hormone that increases metabolic rate.
  • Calcitonin (produced by thyroid gland): Stimulates bone deposition by depletion of calcium from the blood.
  • Parathyroid hormone: Stimulates release of calcium from bones, raising blood calcium levels.
Gastrointestinal hormones:
  • Gastrin: Stimulates gastric secretion.
  • Enterogastrone: Delays emptying of stomach contents.
  • Secretin: Stimulates pancreas and liver secretions.
  • Pancreozymin: Stimulates more concentrated pancreatic secretions.
  • Cholecystikinin: Stimulates gall bladder to release bile into intestines.
Pancreatic hormones (produced by islets of Langerhans):
  • Insulin: Aids in glucose metabolism and glycogen breakdown; deficiency produces diabetes mellitus.
  • Glucagon: Opposite in effect to insulin, stimulates glycogen storage and depletion of glucose from blood.

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