| BLOOD TYPE | Antigens | Antibodies | Can give blood to: | Can receive blood from: | Possible genotypes: |
| A | A | anti-B | A or AB | A or O | AA, Ao |
| B | B | anti-A | B or AB | B or O | BB, Bo |
| AB | A and B | neither | AB only | any type | AB |
| O | neither | anti-A, anti-B | any type | O only | oo |
| Genotype | HbAHbA | HbAHbS | HbSHbS |
| Relative Fitness | 0.85 | 1.00 | 0. |
| Why? | Susceptible to malaria | Resistant to malaria | Sickle-cell anemia (usually fatal) |